The results of the Justification for the Use of Statins in Primary Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER; number. Editorial from The New England Journal of Medicine — JUPITER Clinical Directions — Polling Results. Authors & Reviewers · Submit a Manuscript · Subscribers · Institutions · Media · Advertisers · Agents · Permissions · Reprints · NEJM Career.
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N Engl J Med. Cleve Clin J Med. From Wikipedia, the free encyclopedia.
Michel de Lorgeril, et al. Clinical trials related to cardiology Clinical trials sponsored by AstraZeneca Statins. Since statins lower levels of high-sensitivity C-reactive protein as well as cholesterol, we hypothesized that people with elevated high-sensitivity C-reactive protein levels but without hyperlipidemia might benefit from statin treatment.
In this trial of apparently healthy persons without hyperlipidemia but with elevated high-sensitivity C-reactive protein levels, rosuvastatin significantly reduced the incidence of major cardiovascular events.
The jjupiter analyzed 17, patients without evidence of heart disease but with high CRP levels. Am J Kidney Dis. The trial was stopped after a median follow-up of 1. Retrieved from ” https: Consistent effects were observed in all subgroups evaluated. Jupitrr the role of C-reactive protein, a study employing Mendelian randomizationpublished in the Journal of the American Nejjm Association suggested that CRP does not play a causal role in cardiovascular disease; the results may argue against CRP’s use as a marker of cardiovascular disease risk or for identifying subjects for statin therapy as in JUPITER, and more strongly argue against using CRP as a therapeutic target per se.
They also raised concerns about conflict of interest in the trial design and leadership: Increased levels of the inflammatory biomarker high-sensitivity C-reactive protein predict cardiovascular events.
JUPITER was a randomized double-blind placebo-controlled study investigating the use of rosuvastatin in the primary prevention of cardiovascular disease.
JUPITER trial – Wikipedia
We randomly assigned 17, apparently healthy men and women with low-density lipoprotein LDL cholesterol levels of less than mg per deciliter 3. An I ntervention T rial E valuating R osuvastatin trial was a jupitef trial aimed at evaluating whether statins reduce heart attacks and strokes in people with normal cholesterol levels. Retrieved July 1, The article’s authors critiqued what they saw as flaws in the trial, pointing out that the cardiovascular mortality rate and the case-fatality rate for myocardial infarction were much lower than they expected.
The trial was stopped early, after just 1.
The rates of the primary end point were 0. Compared to patients taking a placebopatients given rosuvastatin had mejm in LDL and CRP levels, and a reduction of 0. The rosuvastatin group did not have a significant increase in myopathy or cancer but did have a higher incidence of physician-reported diabetes.
Comment in Ann Intern Med. Views Read Edit View history. Cardiovascular Quality and Outcomes.
Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein.
Inresults presented at the American Heart Association meeting and published in the New England Jupiher of Medicine found that patients with low-to-normal LDL cholesterol receiving rosuvastatin had a lower rate of major cardiovascular events. Results, Controversies, and Implications for Prevention”. They concluded that, “The results of the trial do not support the use of statin treatment for primary prevention of cardiovascular diseases and raise troubling questions concerning the role of commercial sponsors.
Because half of all vascular events occur in patients with normal or low levels of LDL cholesterol, JUPITER was designed to determine whether hs-CRP testing could identify these patients, and whether statin therapy could prevent cardiovascular events among them. The trial focused on patients with normal low-density lipoprotein LDL cholesterol levels but increased levels of high-sensitivity C-reactive protein hs-CRP.