Radiology. Sep; Granulomatosis infantiseptica. MOORE PH, BROGDON BG. PMID: ; [Indexed for MEDLINE]. MeSH terms. English[edit]. Noun[edit]. granulomatosis infantiseptica (uncountable). (pathology ) Miliary pyogranulomatous lesions on the body as manifestations of neonatal. Listeria monocytogenes is the species of pathogenic bacteria that causes the infection . Surviving neonates of fetomaternal listeriosis may suffer granulomatosis infantiseptica — pyogenic granulomas distributed over the whole body — and.

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granulomatosis infantiseptica – Wiktionary

Listeriosis is a rare but serious infectious disease caused by the bacterium Listeria monocytogeneswhich is predominantly transmitted to humans through the consumption of contaminated food.

Clinical syndromes associated with listeriosis include febrile gastroenteritis, invasive disease sepsis, meningitis, meningoencephalitisand fetal infections causing spontaneous abortions, stillbirth, premature labor, and neonatal disease. Listeriosis most often affects unborn fetuses, newborn infants, older adults, and individuals with weakened immune systems.

Prompt recognition and treatment of the disease is necessary to avoid several serious complications. Symptoms associated with listeriosis may vary widely. Non-pregnant granulomatoxis most often present with bacteremia bacteria in the bloodmeningitis infection of the meninges, the membrane surrounding the brain and spinal cordor meningoencephalitis infection of the meninges and brain.

Common presenting symptoms in patients with bacteremia, meningitis, or meningoencephalitis include fever, muscle aches, headache, stiff neck, malaise, ataxia loss of balanceconvulsions, and mental status granulomatpsis, such as confusion. Less common clinical syndromes include endocarditis infection of the lining of the heartpneumonia, osteomyelitis infection of the boneseptic arthritis infection of the jointabscesses of the brain or liver, peritonitis infection of the membranes lining the abdominal cavityand endopthalmitis infection of structures within the eye.

Symptoms secondary to these conditions depend on the anatomical site of infection and may include abdominal pain, bone pain, respiratory distress, pneumonia, and heart failure. Outbreak investigations have demonstrated that listeriosis can cause febrile gastroenteritis, a noninvasive syndrome, in healthy individuals. Listeriosis during pregnancy can result in fetal loss spontaneous abortion and stillbirthpremature delivery, and neonatal bacteremia or meningitis.

Listeriosis may occur at any time during pregnancy; however, it is most often detected in the third trimester. Among pregnant women diagnosed with listeriosis, most reported only mild flu-like symptoms including fever, chills, muscle aches myalgiasheadaches, joint pain arthralgiaand gastrointestinal symptoms.

Some pregnant women do not recall having had any symptoms before the graunlomatosis of listeriosis in their infant. In contrast to maternal illness, fetal and newborn infections are serious.

granulomatosis infantiseptica

Nearly one-quarter of pregnancy-associated cases result in fetal loss or death of the newborn. Infants with listeriosis neonatal listeriosis may present with fever, lethargy, irritability, diarrhea, poor feeding, vomiting, respiratory distress, or a characteristic skin rash consisting of widely spread, small, pale nodules granulomatosis infantiseptica.

Neonatal listeriosis may be classified as early-onset or late-onset. Early-onset neonatal listeriosis, which occurs in the first 7 days of life, is most often associated with bacteremia or sepsis. Early-onset infections occur following maternal bacteremia with transplacental transmission before birth. Late-onset neonatal listeriosis is most often associated with meningitis.


The mode of transmission is less clear in late-onset listeriosis; environmental sources may be involved in some cases, and outbreaks of hospital-acquired, neonatal listeriosis have been reported.

Listeriosis is caused by the bacterium L. Nearly all cases of listeriosis other than neonatal listeriosis occur from eating contaminated food products, especially ready-to-eat, refrigerated foods.

Unlike most foodborne bacterial pathogens, Granulomatisis. Listeria organisms are commonly found in the environment, including in water, soil, mud, and decaying vegetation.

Numerous outbreaks have been traced to contaminated food products such as infantisepfica or improperly pasteurized milk, soft cheeses, and dairy products, hot dogs, turkey delicatessen meats, and cantaloupe. Invasive listeriosis usually affects pregnant women and their unborn fetuses, newborn infants, older adults, and individuals with weakened immune systems immunocompromised.

Medical risk infantiseptca for invasive listeriosis include hematologic malignancy, organ transplantation, HIV infection or AIDS, alcoholism, and liver and kidney disease. In the United States, L. Comparisons infantiswptica be useful for a differential diagnosis:.

The differential diagnosis of listeriosis includes all causes of meningitis or sepsis in newborn infants, such as group B streptococcus infection; all causes of meningitis and encephalitis in older adults and in individuals with weakened immune systems; and all causes of febrile illness during pregnancy, including viral syndromes.

Rare Disease Database

Granuloatosis B streptococcus group B strep is a type of bacteria that causes infection among newborns, pregnant women, or women after childbirth, women after gynecologic surgery, and older men and women with other serious diseases. Group B strep remains the most common cause among newborns neonates of infection of the blood and of the brain.

The responsible bacterium, usually Streptococcus agalactiae, may be found most often in the vagina and rectum of females and may be transmitted as the granulomatowis passes through the birth canal. Group B strep disease is said to be early onset if it is obvious within the first week of life. It is said to be late onset if the disease is evident after the first week of life and before the end of the first three months. Granulomatosid meningitis is a central nervous system infection caused by certain types of bacteria.

Meningitis granulomarosis characterized by inflammation of the membranes meninges around the brain or spinal cord. Inflammation can begin suddenly infantiiseptica or develop gradually subacute. Major symptoms may include fever, headache, and a stiff neck, sometimes with aching muscles. Nausea, vomiting and other symptoms may occur. Five types of bacteria are responsible for most cases of bacterial meningitis: Haemophilus influenzae, Streptococcus pneumoniae pneumococcusGroup B streptococcus, Neisseria meningitidis meningococcusand Listeria monocytogenes Listeria.

A diagnosis of invasive listeriosis is confirmed through laboratory tests called cultures, which confirm the presence of L. Cultures of blood, amniotic fluid, cerebrospinal fluid, placenta, or specimens from any affected organ systems may be performed to determine whether the bacterium L. Certain x-ray tests such as computed tomography CT scan or granulomatoxis resonance imaging MRI might be infantiseeptica to detect abscesses that may form on internal organs, especially the brain or liver.

Treatment Listeriosis is treated with antibiotics. The most commonly prescribed treatment is intravenous ampicillin. Many physicians also recommend treatment infantideptica the antibiotic gentamicin in combination granulomatsois ampicillin.


For affected individuals who cannot tolerate B-lactam antibiotics such as ampicillintrimethoprim-sulfamethoxazole is recommended. Other antibiotics are sometimes recommended. Antibiotic treatment of pregnant women with documented listeriosis may prevent infection of the fetus. Other treatment is symptomatic and supportive. Prevention Knowing what foods to avoid and how to safely prepare and store foods is the best way to reduce the risk of listeriosis.

This information is most important for those persons in groups at higher risk for invasive listeriosis, especially pregnant women, older adults, grannulomatosis persons who have weakened immune systems. Recommendations for persons at higher risk for listeriosis: Do not eat or drink raw unpasteurized milk or other dairy products. Do not eat soft cheeses such as Brie, feta, and Mexican-style cheeses, unless they are labeled as made from pasteurized milk.

Additionally, be aware that Mexican-style soft cheeses and other Latin-style soft cheeses made from pasteurized milk have also caused listeriosis.

Reheat leftovers, prepackaged foods, and deli meats until steaming hot. Do not eat refrigerated smoked seafood, unless it is contained in a cooked dish, such as a casserole, or unless it is a canned or shelf-stable product.

Wash fruits and vegetables thoroughly if eating raw. Keep unwashed and uncooked foods separate from foods that have been already prepared for eating. The following resource provides additional information: Information on current clinical trials is posted infantisrptica the Internet at www.

All studies receiving U. Some current clinical trials also are posted on the following page on the NORD website: For information about clinical trials sponsored by private sources, contact: For information about clinical trials conducted in Europe, infanttiseptica Resources Please note that some of these organizations may provide information concerning certain conditions potentially associated with this disorder.

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Listeria, Listeriosis, and Food Safety 3rd ed. Taylor and Francis Group, Multistate outbreak of listeriosis associated with cantaloupe.

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Transfusion ; [Epub ahead of print]. New data, strategies, and insights for Listeria monocytogenes dose-response models: Risk Analysis ; [Epub ahead of print]. Hospital-acquired listeriosis outbreak caused by contaminated diced granulomattosis, Clin Infect Dis Jan;56 1: Listeriosis outbreaks and associated food vehicles, United States, — Emerg Infect Dis [Internet] Jan.

Listeria monocytogenes – Wikipedia

PLoS One ;7 7: Epub Jul Clin Infect Dis ; Clin Infect Dis ; Multistate outbreak of Listeria monocytogenes associated with Mexican-style cheese ibfantiseptica from pasteurized milk among pregnant, Hispanic women.

Bacterial meningitis in the United States, Epidemiol Infect ; Swaminathan B, Gerner-Smidt P. The Epidemiology of Human Listeriosis. Reduction in the incidence of invasive listeriosis in Foodborne Diseases Active Surveillance Network Sites, Multistate outbreak of listeriosis linked to turkey deli meat and subsequent changes in US regulatory policy.

Arias Miranda IM, et al. Revision of infantiseptiica cases. Roberts AJ, Wiedemann M.

Pathogen, host and environmental factors contributing to the pathogenesis of listeriosis.