Advancements in Extrusion-Spheronization. More agile techniques are improving the development of multiparticulate drug-delivery systems. Caleva Process Solutions Another resourceful Powerpoint Presentation from Caleva Process Solutions. These selection. Extrusion – to form rod shaped particles of uniform diameter. Spheronization – to round off these rods into spherical particles. Drying – to.

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The ratio of liquid to solid material together with the size of the extruder holes significantly determines the quality of the extrudates. This dough then pressed through an extruder.

The wet mass is added into an LCI Multigranulator MG 55 where it is forced spheronizaton a specific screen to form cylindrical extrudates using either dome, radial or axial extrusion for process optimization. Capsugel is well versed in using drug layering and modified-release coat layering to achieve a range of dissolution profiles in multiparticulate format.

The process consists of extrysion operations. You can disable cookies but parts of spueronization website may not work. We also use cookies on our websites. Moistening the powder mixture, forming cylinder-shaped agglomerate through extrusion, breaking and rounding the extrudate to round pellets through spheronization, and drying the finished product.

Capsugel offers a drug delivery technology to provide oral delivery with full enteric protection and rapid release in the upper gastrointestinal GI tract without the use of coatings. Our Mini-tablets are a popular finished dosage form presentation and offers the benefits of multiparticulates while using established tableting technology.

The technology chosen is dependent upon multiple active ingredient and formulation criteria, e. By continuing to use this website, you spheroniaztion that we may store and access cookies on your device. Register for An Account Already a member? Primary packaging in either vials or sachets and secondary packaging services are also available.


The Extrusion Spheronization Processs

The resultant spheres are dried in a fluid bed dryer and particle size is selected by sieve cuts. The spheres may undergo additional processing steps to apply functional or cosmetic coatings using fluid bed processing with a Wurster insert. Common applications include delayed release, extended release, pulsatile release, and fixed dose combinations.

Cookies allow us to give you the best browsing experience and help us to understand how you use our site. By Product Development Site. The coated spheres may be used for encapsulation, compression, or direct packaging into sachets or pouches for dosing.

The diameter of the openings in the extrusion plate or extrusion basket determines the strength of the elongated extrusion threads spehronization result. Capsugel Dosage Form Solutions is offering a webinar that provides an overview of current taste masking approaches, with emphasis on spheronizaton growing technology options. By visiting our website or using services provided by Lonza, you are accepting the practices described in the Privacy Policy. Application of Multiparticulate Technologies for Drug Delivery.

Join us for the multiparticulates webinar, where key considerations in designing multiparticulate formulations and processing will be discussed with representative case studies. Read more about it here! The final drying ensures the pellet hardness. Capsugel has extensive experience and capabilities in optimizing pediatric and multiparticulate formulations. By clicking “I Agree”, you confirm that you are above the age of 16, that you have read and understood the Privacy Policy and the Cookies Policy, and that you agree sheronization the collection, use and processing of your Personal Information by Lonza in accordance with said policies.


Please read our updated Cookies Policy for information about which cookies we use and the information we collect. Capsugel has extensive experience in designing, formulating and scaling mulitparticulate dosage forms at exrtusion, pilot and commercial scales.

Agglomeration through extrusion and spheronization is one of the oldest techniques for manufacturing pellets. For technical reasons, the resulting pellets are larger than micrometers.

Overview of the Extrusion-Spheronization Process

The process consists of four process steps: In other industries, the size of the pellets can be several centimeters. In the pharmaceutical industry, pellets of medium particle sizes from to 2, micrometers are used for most applications.

The wet extrudate is added to an LCI Marumerizer QJT spheronizer equipped with a high speed spinning plate which forms uniform spheres from the extrudate “rope”. Even if the ball-shaped extrudate is imperfect, the evenness of the surface still creates good conditions for subsequent coating. It is useful for making dense granules for controlled-release solid oral dosage forms with a minimum amount of excipients, as well as multiparticulates used for immediate, modified, or sustained-release.

Just the way you need it. For many pharmaceutical applications, extruded pellets are achieved in suitable quality if a sufficient portion of microcrystalline cellulose is added. The dry, mixed, powdery active substances are kneaded into a dough with a liquid. Please note that Lonza has updated its Privacy Policy.