Br J Pharmacol. Oct;(4) doi: /j x. Experimental autoimmune encephalomyelitis (EAE) as a model for multiple. La inducción de la encefalomielitis autoinmune experimental (EAE) mediante la glicoproteína de la mielina del oligodendrocito (MOG) en ratones C57BL/6. Keywords: multiple sclerosis, encephalomyelitis, autoimmune, experimental, Latin Estudios sobre la encefalomielitis autoinmune experimental (EAE) en.

Author: Mizahn Salkis
Country: Armenia
Language: English (Spanish)
Genre: Environment
Published (Last): 25 May 2013
Pages: 18
PDF File Size: 5.96 Mb
ePub File Size: 1.9 Mb
ISBN: 338-2-38097-740-3
Downloads: 92575
Price: Free* [*Free Regsitration Required]
Uploader: Yozshushura

An unexpected error occurred. According encefalomkelitis the results, the diseased animals exhibited increased levels of IL mRNA, in agreement with the data published by other authors working on this model [34]. Las mediciones se realizaron por triplicado. If that doesn’t help, please let us know.

Experimental autoimmune encephalomyelitis

The model for primary progressive MS is the Theiler’s virus model. Another possibility is to hang the mice from the tail during the clinical evaluation extension reflex.

Mouse models for encefalomielitie sclerosis: As with all types of experiments, controls are crucial. The experimental protocol was submitted for review to the institutional reviewing committee for the use and handling of laboratory animals of the Center for Genetic Engineering and Biotechnology CIGB, Cubaaccording to current international standards [12].

Wikimedia Commons has encefalommielitis related to Experimental autoimmune encephalomyelitis. From a molecular perspective, it was shown that effector cytokines mainly IL were positively regulated in the brain of rncefalomielitis animals. The reactions have been diverse according to the sources of the disease [11] [12] [13] The researchers in the last report have termed the condition “Human autoimmune encephalitis” HAE.


In the negative control group, body weight increased steadily throughout the study, at a rate above that of diseased animals. Por lo tanto, otros expefimental animales tales como el modelo cuprizone se pueden utilizar para el estudio distinto de desmielinizante procesa Desechar el sobrenadante y repetir el paso de lavado. Proper formation of the emulsion was verified by placing one drop onto a Petri dish containing PBS.

Body weight loss was associated with clinical deterioration at the initial stages of the experiment.

A total of microphotographies were analyzed in this study. Cassan C, Liblau Experimentla. In other projects Wikimedia Commons. Animals of the placebo-treated EAE group exhibited high clinical scores evidencing the appearance and progression of the disorder, whereas the animals treated with hydrocortisone improved significantly when compared to the diseased individuals.

Los pares de cebadores. A low-viscosity epoxy resin embedding medium for electron microscopy. Key clinical features Classic EAE in mice causes so-called flaccid paralysis characterized by decreased muscle tone that progresses from the tail upward along the body. IL plays an important role in the development of encefalomoelitis autoimmune encephalomyelitis.

DeCS Server – List Exact Term

Immune tolerance and control of CNS autoimmunity: Oral versus intravenous steroids for treatment of relapses in multiple sclerosis. The sheer number of permutations of EAE models makes their use a minefield for experimental error, and diving into the literature is often not enough to encefalomielihis the needed level of expertise to use EAE most effectively, Becher says.

Spinal and spino-bulbo-spinal reflexes in rats with experimental allergic encephalomyelitis. The typical susceptible rodent will debut with clinical symptoms around two weeks after immunization and present with a relapsing-remitting disease.


Experimental Autoimmune Encephalomyelitis | Multiple Sclerosis Discovery Forum

Se centrifuga a 1. Figure 1A shows average clinical indexes for each experimental group, per day.

During some stages, clinical evaluation may not follow or mimic the behavior of molecular parameters, and body weight was therefore explored solely in a descriptive manner. It is mostly used with rodents and is widely studied as an animal model of the human CNS demyelinating diseases, including multiple sclerosis and acute disseminated encephalomyelitis ADEM.

Experimental Autoimmune Encephalomyelitis

Statistical analysis Statistical analyses were performed using the Prism 5. Zamvil SS, Steinman L. Natural recovery and protection from autoimmune encephalomyelitis: Un curso de la enfermedad representante de ratones EAE se muestra en la Figura 1. This caveat applies especially in drug testing, they say. EAE is also the prototype for T-cell-mediated autoimmune disease in general.

The pathology of MS: You must be signed in to post a comment. A Case Report and Review of the Literature. The counter-regulatory mechanisms of resolution of inflammation and remyelination also occur in EAE, which, therefore can also serve as a model for these processes.

Experimental Autoimmune Encephalomyelitis Animal description Experimental autoimmune encephalomyelitis EAE is the oldest and most frequently used model system for studying MS in laboratory animals. For example, T-cell receptor TCR transgenic mice carry T cells engineered to respond to specific brain antigens.