Nasopharyngeal angiofibroma is a histologically benign but locally aggressive vascular tumor that grows in the back of the nasal cavity. It most commonly affects adolescent males and may grow into fissures of the. Nasoangiofibroma youth is a highly vascularized tumor almost exclusively male adolescents presentation. % represents % of head and. Angiofibroma nasofaring juvenile – Free download as PDF File .pdf), Text File . txt) or read online for free.
|Published (Last):||12 December 2018|
|PDF File Size:||20.95 Mb|
|ePub File Size:||15.42 Mb|
|Price:||Free* [*Free Regsitration Required]|
Juvenile nasopharyngeal angiofibroma JNA is a benign neoplasm of the nasopharynx. Intricate mixture of stellate and staghorn blood vessels with variable vessel wall thickness ranging from single layer of endothelium to variable smooth muscle coat Irregular fibrous stroma loose, edematous to dense, acellular Stromal cells are stellate fibroblasts with small pyknotic to large vesicular nuclei Larger vessels at base of lesion, smaller vessels with plump endothelial cells at angiofibroms edge of tumor Multinucleated stromal cells are common Mitotic figures are rare Minimal inflammation.
Home About Us Advertise Amazon. On palpation, the swelling was firm and nontender. Click here for patient related inquiries.
Nasopharyngeal angiofibroma – Wikipedia
JNA is an uncommon benign tumor predominantly affecting adolescent males. Based on the clinical and radiological features, JNA is classified into three types.
They account for only 0. Axial section in computed tomography demonstrating obliteration of the nasal cavity and maxillary sinus. A typical staghorn type appearance is seen. He also complained of difficulty in breathing since 6—7 months.
Intraoral swelling was diffuse, obliterating the vestibule and extending from the lateral incisor anteriorly till the pharynx posteriorly [ Figure 1 ]. Page views in Support Radiopaedia and see fewer ads.
This tumor originates in the lateral wall of the naasofaring cavity, close to the superior border of the sphenopalatine foramen. Preoperative embolisation of tumour may be of some use in reducing intraoperative bleeding. The prevalence in males may be explained by high androgen receptor AR expression suggesting that JNA is androgen dependent.
MRI is used posttreatment to detect residual or recurrent tumor mass and to monitor the effects of radiotherapy. Diagnosis is arrived at by clinical examination, radiography, nasal endoscopy and specialized imaging techniques such as CT scan and MRI.
They may be locally aggressive. Juvenile nasopharyngeal angiofibroma JNA is a rare benign tumor arising predominantly in the nasopharynx of adolescent males. Advanced lesions with orbital and intracranial extension are difficult to treat and may recur often. Consistent expression of estrogen receptor beta. Steroid hormone receptor expression in nasopharyngeal angiofibromas. JNA classically presents as a painless, progressive unilateral nasal obstruction.
Nasal cavity, paranasal sinuses, nasopharynx Other tumors Nasopharyngeal angiofibroma Author: Mesothelioma Malignant solitary fibrous tumor. This may be attributed to a rich vasculature and lack of encapsulation. The color depends on the vascular component and may vary from pale white in less vascular lesions to a pink and wine colored mass in highly vascularized ones.
Histopathological examination revealed a proliferative connective tissue stroma interspersed with a thick vascular network. J Clin Imaging Sci. Sagittal section in computed tomography scans showing site and extent nasofaribg the lesion.
Case 7 Case 7. Intraoral view showing swelling on the upper left side of the maxilla and obliteration of the vestibule. Avid enhancement is noted on contrast-enhanced CT. InFriedberg called it juvenile angiofibroma. Nasopharyngeal angiofibroma also called juvenile nasopharyngeal angiofibroma   is a histologically benign but locally aggressive vascular tumor that grows in the back of the nasal cavity.
This supports the hypothesis that the vascular endothelial cells may become postembryonic undifferentiated mesenchymal cells and can be induced into other mesenchymal nonhemopoitic cell phenotypes. Nasopharyngeal angiofibroma[TI] free full text[sb]. Biopsy should be avoided as to avoid extensive bleeding since the tumor is composed of blood vessels without a muscular coat.
It is, as the name suggests, very vascular and a biopsy can sometimes be fatal. Juvenile nasopharyngeal angiofibromas are benign but highly vascular nawofaring. As this tumor is aggressive and expansile, it invades adjacent structures causing further symptoms.
Juvenile nasopharyngeal angiofibroma | Radiology Reference Article |
Surgery difficult to excisepreoperative embolization or antiandrogen therapy Chemotherapy or radiation therapy if advanced or aggressive. MRI is superior to CT for detecting soft tissue extension of the tumor intracranially.
Findings are similar to those described above. Genetic alterations in juvenile nasopharyngeal angiofibromas. Arteriography followed by preoperative embolization and surgical resection is the treatment of choice.
See staging of juvenile nasopharyngeal angiofibromas. However, since a vast majority of the cases do occur between 14 and 25 years of age, this term is retained. JNA is classified as Type I when the tumor is restricted to the nasal cavity and the nasopharynx without bone destruction, Type II when the tumor invades the pterygomaxillary fossa and maxillary, sphenoidal and ethmoid sinuses with bone destruction, Type III when the tumor invades the infratemporal fossa, the orbit, and the parasellar region but remains lateral to the cavernous sinus and Type IV when the tumor invades the cavernous sinus, the optic chiasma and the pituitary fossa.
Author information Article notes Copyright and License information Disclaimer. Accordingly, the treatment options, operative approach and prognosis can be determined. The location and size nasofarinv the tumor and feeding vessels are clearly demonstrated by this technique.